Anillin
نویسندگان
چکیده
Are there homologues outside of metazoa? In the fission yeast Schizosaccharomyces pombe there are two anillin-like proteins, Mid1p and Mid2p, which have nonoverlapping functions. Mid1p is a key regulator of cytokinesis, orchestrating contractile ring positioning and assembly. Mid2p has a less essential role, acting later in cytokinesis to organize septins during septation. Budding yeast (Saccharomyces cerevisiae) anillin-like proteins Boi1p and Boi2p have carboxy-terminal PH domains, localize to the nucleus and the contractile ring at the bud neck, and act late in cytokinesis to protect against severing of unsegregated chromatin.
منابع مشابه
The septin-binding protein anillin is overexpressed in diverse human tumors.
Anillin is an actin-binding protein that can bind septins and is a component of the cytokinetic ring. We assessed the anillin expression in 7,579 human tissue samples and cell lines by DNA microarray analysis. Anillin is expressed ubiquitously but with variable levels of expression, being highest in the central nervous system. The median level of anillin mRNA expression was higher in tumors tha...
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Anillin is a scaffolding protein that organizes and stabilizes actomyosin contractile rings and was previously thought to function primarily in cytokinesis [1-10]. Using Xenopus laevis embryos as a model system to examine Anillin's role in the intact vertebrate epithelium, we find that a population of Anillin surprisingly localizes to epithelial cell-cell junctions throughout the cell cycle, wh...
متن کاملStabilization of the Actomyosin Ring Enables Spermatocyte Cytokinesis in Drosophila
The scaffolding protein anillin is required for completion of cytokinesis. Anillin binds filamentous (F) actin, nonmuscle myosin II, and septins and in cell culture models has been shown to restrict actomyosin contractility to the cleavage furrow. Whether anillin also serves this function during the incomplete cytokinesis that occurs in developing germ cells has remained unclear. Here, we show ...
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The clinical course of renal cell carcinoma (RCC) can be difficult to predict. In this study we evaluated the prognostic value of anillin and Ki-67 in predicting survival in RCC. Immunohistochemical analysis using anillin and Ki-67 antibodies was performed on tissue microarrays constructed from paraffin-embedded specimens from 152 patients with primary RCC. The mean follow-up time was 90 months...
متن کاملRho-dependent control of anillin behavior during cytokinesis
Anillin is a conserved protein required for cytokinesis but its molecular function is unclear. Anillin accumulation at the cleavage furrow is Rho guanine nucleotide exchange factor (GEF)(Pbl)-dependent but may also be mediated by known anillin interactions with F-actin and myosin II, which are under RhoGEF(Pbl)-dependent control themselves. Microscopy of Drosophila melanogaster S2 cells reveal ...
متن کاملFunctional Analysis of a Human Homologue of the Drosophila Actin Binding Protein Anillin Suggests a Role in Cytokinesis
We have characterized a human homologue of anillin, a Drosophila actin binding protein. Like Drosophila anillin, the human protein localizes to the nucleus during interphase, the cortex following nuclear envelope breakdown, and the cleavage furrow during cytokinesis. Anillin also localizes to ectopic cleavage furrows generated between two spindles in fused PtK(1) cells. Microinjection of antian...
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عنوان ژورنال:
- Current Biology
دوره 20 شماره
صفحات -
تاریخ انتشار 2010